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On the safety question: before any trial begins, an Independent Ethics Committee or Institutional Review Board (IRB) reviews the entire study design

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Thus, the conditional metabolic buffer hypothesis predicts a narrow therapeutic window in which enhancing controlled lipid utilization or improving lipid handling capacity could be beneficial, whereas indiscriminate stimulation of fatty acid oxidation may be harmful if antioxidant capacity or mitochondrial function is insufficient

This complicates the diagnosis, since false negative results can occur [40]

Treatment of new-onset epilepsy